![]() Gene expression in the human prefrontal cortexĪ multi-modal, cross-disorder platform for integrated neuroscience research and data by the Ontario Brain Institute. Online resource for information about neural circuitry Meta-analysis and database of MRI studies Multilevel: brain regions, connections, neurons, gene expression patterns © 2010 Wiley-Liss, Inc.Data (MRI, fMRI, images, descriptive, numerical)Ītlas, stained sections from brains showing development and gene expressionĪlzheimer's Disease Neuroimaging Initiative (ADNI)ģD reconstruction of complete brain from cell-body stained histology sections at 20 micron isotropic resolutionįMRI, MRI scans and atlases for human and mouse brains Given the limited availability of brain metabolic resources, these findings suggest that prolonged states of reduced water intake may adversely impact executive functions such as planning and visuo-spatial processing. This pattern indicates that participants exerted a higher level of neuronal activity in order to achieve the same performance level. ![]() The increase in BOLD response after dehydration was not paralleled by a change in cognitive performance, suggesting an inefficient use of brain metabolic activity following dehydration. ![]() Dehydration following the thermal exercise protocol led to a significantly stronger increase in fronto-parietal blood-oxygen-level-dependent (BOLD) response during an executive function task (Tower of London) than the control condition, whereas cerebral perfusion during rest was not affected. Subjects lost more weight via perspiration in the thermal exercise versus the control condition (P < 0.0001), and lateral ventricle enlargement correlated with the reduction in body mass (r = 0.77, P = 0.01). Each subject completed a thermal exercise protocol and nonthermal exercise control condition in a cross-over repeated measures design. We investigated this question using functional magnetic resonance imaging (fMRI) in 10 healthy adolescents (mean age = 16.8, five females). However, the effects of dehydration on brain function are unknown. ![]() Negative effects of dehydration on cognitive performance have been shown in some but not all studies, and it has also been reported that an increased perceived effort may be required following dehydration. It was recently observed that dehydration causes shrinkage of brain tissue and an associated increase in ventricular volume. ![]()
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